A recent study reveals that people who stop using new GLP-1 drugs like semaglutide or tirzepatide can put back on shed pounds at a significantly accelerated pace than those who stop conventional diet and exercise plans.
Findings released in a leading health publication points out that while obese people can lose substantial amounts of their body weight while using the jabs, the mass is regained at an estimated rate of nearly a kilo each month after stopping.
"Users using such treatments need to be informed of the danger of rapid rebound weight gain when the therapy is stopped," cautioned researcher Dr. Susan Jebb.
Such speed of regain suggests a return to original mass in about 18 months.
Comparing Therapies
The research, which looked at 37 of trials involving thousands of participants, contrasted the results of GLP-1 agonists with older methods.
Researchers point out that people who shed pounds through lifestyle changes alone typically see a slower weight regain—around 100 grams monthly—once they finish.
Explaining the Quick Regain
Experts believe the mechanism of the jabs explains the accelerated weight return.
The injections mimic a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Sustained high doses of the hormone concentrations far above than the body's typical production could lead to the body to produce less of its endogenous GLP-1, and could diminish sensitivity to its actions," noted Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this hormone supplement results in hunger is no longer kept in check, making excessive eating much more probable."
A Chronic Disease?
The NHS recommend the injections for people with obesity-related medical conditions, alongside recommended lifestyle changes.
Many experts contend that, due to the significant potential of weight regain, the therapy might need to be ongoing.
This perspective is reinforced by pharmaceutical companies, who note that the findings "highlight the long-term nature of obesity," similar to managing conditions like diabetes.
Patient Experiences
People who have stopped the medication report a powerful resurgence of hunger.
"It felt as if a switch activating and you're instantly extremely hungry," described a patient.
The struggle is exacerbated if patients have not adopted permanent dietary or behavioural changes during treatment.
Significant Interest
Survey data suggest that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with interest being substantial.
- Use is more common among women compared to males.
- The 40s and 50s demographic shows the highest usage rates.
- Many obtain the medications through private healthcare rather than public health services.
Finally, researchers stress that while the jabs are potent agents for shedding pounds, they are not a magic cure and lasting health benefits relies on integrated behavioural changes.
